CC chemokine ligand 25 enhances resistance to apoptosis in CD4+ T cells from patients with T-cell lineage acute and chronic lymphocytic leukemia by means of livin activation.

Acute and Chronic Lymphocytic Leukemia by Means of T Cells from Patients with T-Cell Lineage

We investigated CD4 and CD8 double-positive thymocytes, CD4 T cells from typical patients with T-cell lineage acute lymphocytic leukemia (T-ALL) and T cell lineage chronic lymphocytic leukemia (T-CLL), and MOLT4 T cells in terms of CC chemokine ligand 25 (CCL25) functions of induction of resistance to tumor necrosis factor (TNF)–mediated apoptosis. We found that CCL25 selectively enhanced resis...

CD4+ T Cells are Exhausted and Show Functional Defects in Chronic Lymphocytic Leukemia

Background: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. This health problem is caused due to the accumulation of mature B-lymphocytes in the peripheral blood and bone marrow. In the course of cancer, CD4+ T cells become “exhausted” and characterized with poor effector functions and the expression of multiple inhibitory receptors. Objective: To inve...

Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia.

In a total of 38 typical T-cell lineage acute lymphocytic leukemia (T-ALL) and T-cell lineage chronic lymphocytic leukemia (T-CLL) cases investigated, we found that CC chemokine receptor CCR9 was selectively and frequently expressed on T-ALL CD4+ T cells, was moderately expressed on T-CLL CD4+ T cells, and was rarely expressed on normal CD4+ T cells. These findings were demonstrated at protein ...

سطح بالای پاسخ ایمنی اختصاصی لنفوسیت‌های CD4+وCD8+ نسبت به سیتومگالوویروس و همبستگی بین آن‌ها در بیماران مبتلا به لوسمی لنفوسیتی مزمن سلولB

  High level of CMV-specific CD4+ and CD8+cells Immune Response and Correlation Between them in B-cell Chronic Lymphocytic Leukemia Patients     B. Pourgheysri [1] , P. Moss [2]     Received: 10/09/07 Sent for Revision: 05/03/08 Received Revised Manuscript: 06/12/08 Accepted: 30/12/08   Background and Objective: Chronic lymphocytic leukemia (CLL) is characterized by a monoclonal proliferation o...

B Cells + CD 5 + CD 23 Acute and Chronic Lymphocytic Leukemia Resistance to Apoptosis in B Cell Lineage Chemokine Ligand 19 Cooperatively Render CXC Chemokine Ligand 13 and CC